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Friday, July 17, 2020 | History

2 edition of Molecular pharmacology of chimeric peptides. found in the catalog.

Molecular pharmacology of chimeric peptides.

Michelle Jane Farquhar

Molecular pharmacology of chimeric peptides.

by Michelle Jane Farquhar

  • 55 Want to read
  • 18 Currently reading

Published by University of Wolverhampton in Wolverhampton .
Written in English


Edition Notes

Dissertation (Ph.D.) - University of Wolverhampton 2002.

ID Numbers
Open LibraryOL18787673M

The molecular TH technology has evolved from initial investigations of the basic biology of endogenous BBB transporters. Download: Download full-size image; Figure 2. Blood–brain barrier Trojan horse technology. A chimeric peptide is formed by fusing a nontransportable drug, D, to a BBB molecular Trojan horse, by: Journals & Books; Help; we have compared the structural and pharmacological characteristics of several chimeric peptides derived from peptide E and β-endorphin. Structures were obtained under the same experimental conditions using circular dichroism, computational estimation of helical content and/or nuclear magnetic resonance spectroscopy Cited by: 3.

  The galanin neuropeptide system is widely distributed throughout the brain and periphery and is thought to play a role in feeding, pain and reproduction. To evaluate the human galanin receptor 1 as a potential therapeutic target, we fully characterized its interaction with several galanin-like peptides. The human galanin receptor 1 receptor was stably expressed using an episomal system in Cited by: In this paper, a self‐delivery chimeric peptide PpIX‐PEG 8 ‐KVPRNQDWL is designed for photodynamic therapy (PDT) amplified immunotherapy against malignant melanoma. After self‐assembly into nanoparticles (designated as PPMA), this self‐delivery system shows high drug loading rate, good dispersion, and stability as well as an excellent capability in producing reactive oxygen species Cited by: 2.

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki , Greece Interests: synthesis and biological studies on anti-inflammatory and antioxidant agents, on inhibitors of enzymes implicated in the inflammation and in the coagulation process in general; correlation of inflammation with cancer; neurodegeneration; antioxidant activity. The patent titled “Chimeric Fibronectin Matrix Mimetics and Uses Thereof” (US 9,,) has recently been assigned to the University of Rochester with inventors Denise C. Hocking, Ph.D. (Pharmacology and Physiology, BME, RCBU) and Daniel Roy, Ph.D. (BME PhD alumnus). The patent relates to a series of recombinant fibronectin peptide.


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Molecular pharmacology of chimeric peptides by Michelle Jane Farquhar Download PDF EPUB FB2

Discover the best Molecular Pharmacology in Best Sellers. Find the top most popular items in Amazon Books Best Sellers. Molecular pharmacology of chimeric peptides. (Thesis) Farquhar MJ. Publisher: University of Wolverhampton [] Metadata Source: The British Library Type: Thesis.

Abstract. Highlight Terms No biological terms identified No abstract supplied. Menu Formats. Abstract; Thesis at EThOS. Molecular pharmacology of chimeric peptides Author: Farquhar, Michelle Jane.

ISNI: Awarding Body: University of Wolverhampton Current Institution: University of Wolverhampton Date of Award: Availability of Full Text: Access from EThOS. Additional details of chimeric peptide synthesis are also provided elsewhere in this volume. Molecular pharmacology of chimeric peptides.

book chapter also explores some of the more common applications of chimeric peptides with particular emphasis on the molecular pharmacology of sequences that include address motifs for G protein-coupled receptors. By highlighting the interdisciplinary and dynamic nature of pharmacological research, this text book integrates the essential aspects of molecular pharmacology in a printed section and also presents the most recent research achievements on each subject as a long list of electronic supplements for those interested in a deeper approach, either for professional use or as study material.5/5(5).

The book is very informative for researchers in excellent book if you want to know the basics of molecular pharmacology and experimental off to terry kenakin.

Read more. Helpful. Comment Report abuse. See all reviews from the United StatesCited by: Chimeric peptides combine two or more bioactive modules in a single molecule.

Previous studies have demonstrated that MP-containing chimeric constructs exhibit G protein-coupled receptor (GPCR)-independent actions dissimilar to those of their individual components [2].Author: Michelle Farquhar, Ursel Soomets, Ashley Martin, Ülo Langel, John Howl.

His main scientific interest is in peptide chemistry, bioactive peptides., and their application in biochemistry and medical sciences. He has authored more than publications and together with Hans-Dieter Jakubke, has written the book Peptides from A. Coeluting peptides are still a major challenge for the identification and validation of MS/MS spectra, but carry great potential.

To tackle these problems, we have developed the here presented CharmeRT workflow, combining a chimeric spectra identification strategy implemented as part of the MS Amanda algorithm with the validation system Elutator, which incorporates a highly accurate retention Cited by: Endogenous peptides and proteins include well characterized families of neuropeptide transmitters, neuropeptide modulators, hormones, and fragments of functional proteins, which are essential in many biological processes.

The peptides exert potent biological actions in virtually all systems in the body (see figure for examples). Pharmaceutical products which mimic the effects of endogenous. Books Advanced Search New Releases Best Sellers & More Children's Books Textbooks Textbook Rentals Best Books of the Month of results for Books: Medical Books: Pharmacology: Molecular.

Therapeutic Proteins and Peptides, Volume in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides.

Title: Biological Applications of the Receptor Mimetic Peptide Mastoparan VOLUME: 7 ISSUE: 6 Author(s):Sarah Jones and John Howl Affiliation:Molecular Pharmacology Research Group, Research Institute in Healthcare Sciences, University of Wolverhampton, Wolverhampton, UK.

Keywords:Mastoparan, G protein-coupled receptors, chimerism, secretion, cytotoxicity, analogues, α Cited by: Calcitonin gene-related peptides (α and β isoforms), better known as CGRPα and CGRPβ, were isolated 20 years ago.

In fact, these were the first peptides to be characterized using a molecular cloning strategy, which is not the traditional approach of biochemical extraction and by:   The melanocortin receptors MC1 and MC3 are G protein-coupled receptors that have substantial structural similarities and bind melanocyte peptides but with different affinity profiles.

We constructed a series of chimeric MC1/MC3 receptors to identify the epitopes that determine their selectivities for natural melanocyte peptides and synthetic by:   Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level.

This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as Book Edition: 1. Relaxin-3, the most recently identified member of relaxin/insulin family, is an agonist for leucine-rich repeat-containing G protein-coupled receptor (LGR)7, GPCR, and GPCR LGR7 can be pharmacologically differentiated from GPCR and GPCR by its high affinity for relaxin.

Selective ligands that specifically activate GPCR or GPCR are highly desirable for studying their Cited by: Several hundred mutant receptors (]ossi Schles- singer, Rorer Pharmaceuticals Inc., King of Prussia) and chimeric receptors (Axel Ullrich, Max- Planck-Institut f~r Biochemie, Martinsried) have been syn- thesized to analyse in more detail the molecular requirements for signalling through this receptor by: 9.

Peptide design and structure analysis. Herein, we synthesized chimeric peptides consisting of the wound healing promoting peptide Tylotoin 15 Cited by: 1. Ligand-binding studies were employed using a rat liver V1a vasopressin receptor preparation and both peptide and non-peptide receptor ligands.

Synthetic peptides corresponding to defined regions of the extracellular surface of the neurohypophysial hormone Cited by:. The analysis of chimeric proteins, which are constructed from similar membrane transporters, is an effective method to determine the role of large structural domains while lowering disruption in protein folding [23, 24].

Doring et al [22] has engineered a recombinant chimeric peptide transporter, CH1Pep. This construct has been used to identify.Chimerism: a strategy to expand the utility and applications of peptides.

Howl J(1). Author information: (1)Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, UK. The modular nature of peptides can be exploited in the synthesis of chimeric sequences that combine diverse motifs in a single by: Additional details of chimeric peptide synthesis are also provided elsewhere in this volume.

This chapter also explores some of the more common applications of chimeric peptides with particular emphasis on the molecular pharmacology of sequences that include address motifs for G protein-coupled : John D. Howl.